Nutrition and Outcomes of Hematopoietic Cell Transplantation (HCT)

Imperial College Healthcare NHS Trust

Status: Completed

Conditions: Hematologic Malignancy; Graft Versus Host Disease; Allogeneic Stem Cell Transplant; Stem Cell Transplant Complications

Study type: Observational

Funder types: Other

Identifiers

NCT03419078

15HH2638

Details and patient eligibility

About

Retrospective case-note review to determine if nutrition via the enteral compared to the parenteral route results in better outcomes after haematopoietic cell transplantation.

Full description

This is a retrospective case-note review of adults undergoing haematopoietic cell transplantation to treat a haematological malignancy who have been admitted to Hammersmith Hospital from 2000 to 2014. All patients receiving an allogeneic haematopoietic cell transplant from a matched sibling or identically matched unrelated donor will be included. We will record the route and assess the broad adequacy of nutritional intakes to determine if nutrition via the enteral compared to the parenteral route results in better outcomes after haematopoietic cell transplantation. Our outcomes are graft versus host disease incidence and severity, transplant related (early) mortality and overall survival.

Enrollment: 484 patients

Sex: All

Ages: 17+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing their first HCT for a hematologic malignancy
• Undergoing HCT using a sibling or unrelated donor
• Undergoing HCT infusion between January 2000 and December 2014

Exclusion criteria

• HCT using umbilical cord blood donors
• HCT using haploidentical donors