Nutrition Status, BMD, and SSRIs

University of New Mexico (UNM)

Status: Terminated

Conditions: BMD

Treatments: Diagnostic Test: Dual-Energy X-ray Absorptiometry (DXA)

Study type: Observational

Funder types: Other

Identifiers

NCT03383861

174318

Details and patient eligibility

About

The association between selective serotonin reuptake inhibitor (SSRI) use and bone mass density (BMD) has been debated. Some have suggested features of depression, which SSRIs are prescribed to treat, may be a cause of decreased BMD, such as poor overall food intake at the time of SSRI use. Our study seeks to determine whether SSRI use in adults is associated with lower than average BMD, and if there is an association between low micronutrient intake, SSRI use, and a low BMD.

Enrollment: 13,027 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Included adult NHANES participants are those who participated in the Dual-Energy X-ray Absorptiometry (DXA) femur-neck BMD test and responded in full to the demographic, pharmaceutical, and dietary surveys.

Exclusion criteria

• Pregnancy, incomplete survey responses, incomplete DXA results

Trial design

13,027 participants in 2 patient groups

SSRI long-term user

Description:

Adults, 655 with an SSRI prescription ≥180 days and identified in the National Health and Nutrition Examination Survey (NHANES) data.

Treatment:

Diagnostic Test: Dual-Energy X-ray Absorptiometry (DXA)

Non-user

Description:

Adults, 12,372 non-users, were identified in the National Health and Nutrition Examination Survey (NHANES) data.

Treatment:

Diagnostic Test: Dual-Energy X-ray Absorptiometry (DXA)