Nutritional Evaluation of Canola Protein in Comparison With Soy Protein

University of Jena

Status: Completed

Conditions: Men

Treatments: Dietary Supplement: Protein drink - protein isolate; Dietary Supplement: Protein drink - protein hydrolyzate

Study type: Interventional

Funder types: Other

Identifiers

NCT01481584

LSEP H43-10

Details and patient eligibility

About

The objective of the study is to evaluate the nutritional and physiological properties of two canola proteins focusing on the bioavailability in humans.

Full description

The physiological effects of a single administration of two different industrially manufactured canola proteins (hydrolyzate, isolate) were investigated compared to soy protein.

Twenty-eight healthy men (ø 25 years) completed a double-blind, placebo-controlled, crossover study. The subjects were randomly divided into two groups (group A: canola protein isolate and soy protein isolate and group B: canola protein hydrolyzate and soy protein isolate). After a three-day run-in period, on the intervention day, the subjects consumed a protein drink containing 30.0 g protein powder added to a final volume of 500 mL tomato juice. Half of the subjects in each group consumed a protein drink containing 30.0 g canola protein, the other half received the soy protein. After taking of fasting blood samples in the morning of the intervention day, blood samples were drawn at regular intervals for a period of eight hours. At the end of the run-in period and on the intervention day, a 24-hour urine collection took place.

Within a second experiment (after 4 weeks), the protein source was crossed within the four subgroups for the second intervention.

Enrollment: 28 patients

Sex: Male

Ages: 20 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Nonsmoker
• Body mass index: 20-26 kg/m²

Exclusion criteria

• Intake of pharmaceuticals
• Allergy against canola protein or soy protein
• Kidney disease

Trial design

Primary purpose: Screening

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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28 participants in 4 patient groups

Canola protein

Experimental group

Description:

Canola protein (Brassica juncea; incorporated in a drink)

Treatment:

Dietary Supplement: Protein drink - protein hydrolyzate

Dietary Supplement: Protein drink - protein isolate

Reference protein

Active Comparator group

Description:

Reference Protein (soy protein isolate; incorporated in a drink)

Treatment:

Dietary Supplement: Protein drink - protein hydrolyzate

Dietary Supplement: Protein drink - protein isolate

Wash out

No Intervention group

Description:

Wash out (four weeks without any intervention between interventional periods)

Run-in

No Intervention group

Description:

Run-in period (three days before intervention, defined diet)