Nutritional Modulation of Cognition and Brain Activity

University of Vienna

Status: Enrolling

Conditions: Cognitive Change; Brain Activity; Nutrition, Healthy

Treatments: Other: Dietary intervention: Standardized breakfast with varying amounts of macronutrients (in particular carbohydrate/protein ratios)

Study type: Interventional

Funder types: Other

Identifiers

NCT06386237

UVienna_NDNL_1

Details and patient eligibility

About

The aim of the present study is to investigate the effects of different meal interventions on cognition (i.e., learning and decision making) and brain activity in healthy participants.

Enrollment: 40 estimated patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18 to 40 years old
• fluent in German
• right-handed
• able to safely undergo MRI scanning
• BMI (Body-Mass-Index) between 18.5 and 29.9 kg/m2

Exclusion criteria

• current medication that might interfere with the processes studied
• any metabolic, gastrointestinal, cardiological, neurological, psychiatric or any recurring or chronic diagnoses
• drug use
• alcohol consumption > 10 g/d for women and > 20 g/d for men
• smoking
• shifted circadian rhythm (e.g. jetlag, shift work)
• vegan or vegetarian diet
• food intolerances
• females: hormonal contraception, pregnancy, lactation

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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40 participants in 2 patient groups

Standardized meal with macronutrient composition 1

Experimental group

Description:

Participants receive a standardized meal with one type of macronutrient composition in one experimental session and the other type in a different experimental session a few days apart (within-subjects crossover design; i.e. order counterbalanced)

Treatment:

Other: Dietary intervention: Standardized breakfast with varying amounts of macronutrients (in particular carbohydrate/protein ratios)

Standardized meal with macronutrient composition 2

Experimental group

Description:

Participants receive a standardized meal with one type of macronutrient composition in one experimental session and the other type in a different experimental session a few days apart (within-subjects crossover design; i.e. order counterbalanced)

Treatment:

Other: Dietary intervention: Standardized breakfast with varying amounts of macronutrients (in particular carbohydrate/protein ratios)