Nutritional Prognostic Factors in ALS (PEG-ALS)

University of Bari

Status

Completed

Conditions

Neuro-Degenerative Disease

Gastrostomy

Nutritional Deficiency

Treatments

Other: Nutritional assessment

Study type

Observational

Funder types

Other

Identifiers

NCT03487536

Policlinic Hospital 2, Bari

Details and patient eligibility

About

Background. Several nutritional factors have been evaluated as prognostic factors for survival in ALS patients at earlier stages of the disease [body mass index (BMI), body composition expressed as fat free mass (FFM), fat mass (FM), phase angle (PhA), low-density lipoprotein/high-density lipoprotein (LDL/HDL) ratio, cholesterol levels], while only two studies have evaluated some of these parameters after PEG placement.

Aim. BMI and cholesterol levels were evaluated as prognostic factors for survival after percutaneous endoscopic gastrostomy (PEG) placement Moreover, the relationship between body composition and BMI in a subgroup of ALS patients was evaluated.

Full description

Methods. Nutritional and neurological parameters were assessed at the time of PEG placement (T0) in 47 consecutive patients. Body composition and PhA were measured in only 22 patients within 2 months from T0. Survival was calculated as the time from the PEG placement to tracheostomy or death.

Enrollment

47 patients

Sex

All

Volunteers

No Healthy Volunteers

Inclusion criteria