Nutritional Status and Hidradenitis Suppurativa (Acne Inversa) (NutriHidra)

Federico II University

Status: Completed

Conditions: Trimethylamine N-oxide (TMAO); Vitamin D Deficiency; Mediterranean Diet; Hidradenitis Suppurativa; Body Composition

Treatments: Dietary Supplement: Mediterranean Diet

Study type: Observational

Funder types: Other

Identifiers

NCT03683238

201/15

Details and patient eligibility

About

Hidradenitis suppurativa (HS) is a chronic inflammatory, debilitating skin disorder. The exacerbating factors of HS include nutrition and adiposity. The objective of this study was to investigate the relationships between body composition and the adherence to the Mediterranean diet (MD) with the severity of HS in a sample of naïve-treatment patients with HS. In the wake of this evidence, in the study to investigate the relationships between nutritional status, the adherence to the MD, body composition, and the severity of HS in a sample of naïve-treatment patients with HS compared to control group matched for sex, age, and body weight.

Enrollment: 81 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy subjects of both gender
• treatment-naïve patients
• had HS diagnosed ≥6 months before study initiation wash out therapy for at least 3 months

Exclusion criteria

• occasional or current of use of drugs for HS, including topical antibiotics and systemic treatments (such as clindamycin-rifampicin, tetracycline, Rifampicin-moxifloxacin-metronidazole, ertapenem, acitretin, cyclosporine A, dapsone, isotretinoin, biologics;
• hypocaloric diet in the last three months or specific nutritional regimens;
• vitamin/mineral or antioxidant supplementation;
• occasional or current of use of drugs that could influence fluid balance, including non-steroidal anti-inflammatory drugs, hormone replacement therapy.