Nutritional Study to Determine the Effect of Fish Oil on Atopic Dermatitis (CetoSkin)

Møreforsking AS

Status: Enrolling

Conditions: Atopic Dermatitis

Treatments: Dietary Supplement: LC-MUFA oil; Dietary Supplement: Placebo

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT06194045

589440

Details and patient eligibility

About

Atopic Dermatitis is associated with pronounced changes in the lipid composition in the skin. The lipid changes are influenced by and contributing to both the inflammatory circuit and the impaired barrier as well as changes in the skin microbiome This nutritional study will investigate the effect of long-chain monounsaturated fatty acid Cetoleic acid on atoptic dermatitis. Earlier studies have shown a anti-inflammatory effect of celoteic acid.

Full description

Women and men will be recruited to a placebo or a cetoleic-rich fish oil group and be examined for the effect on atopic dermatitis before, during and after the study period.

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Women and men 18-80 years of age.
• Diagnosed with active mild to moderate atopic dermatitis with an EASI of 1.1- 21.0.
• Willing to refrain from oil supplements (omega-3, borage, evening primrose, etc.) for 1 month before study begin (washout) and during the study
• Willing to take the study supplement for 6 months

Exclusion criteria

• Known allergy to fish products
• Subjects known to be pregnant or breast feeding
• Subjects perceiving systemically administered medication for AD (other than topical)
• Subjects with auto-immune diseases (except asthma and seasonal/perennial rhinitis)
• Subjects with a diagnosis of other skin diseases

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

---

60 participants in 2 patient groups, including a placebo group

LC-MUFA oil

Experimental group

Description:

2x1g capsules containing concentrated marine oil from north atlantic fish

Treatment:

Dietary Supplement: LC-MUFA oil

Placebo

Placebo Comparator group

Description:

2x1g capsules containing corn oil

Treatment:

Dietary Supplement: Placebo