Nutritional Supplementation in Cognitive Aging

University of Cincinnati

Status: Completed

Conditions: Cognitive Aging

Treatments: Dietary Supplement: whole fruit blueberry powder; Dietary Supplement: Concord grape juice; Dietary Supplement: berry placebo powder; Dietary Supplement: blueberry juice; Dietary Supplement: placebo juice

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT00599508

06-03-20-08

Details and patient eligibility

About

To evaluate the effect of supplemented berry fruit juice and whole fruit berry powder on memory performance and brain function in older adults

Full description

Randomized trials involving daily supplementation with berry fruits in older adults with early memory changes. The berry products include Concord grape juice, blueberry juice, and whole fruit blueberry powder. Supplementation periods are 12 and 16 weeks, depending on berry product. The Aims of the studies are to assess effects on cognitive performance and in a subset of participants, in brain activity.

Enrollment: 120 patients

Sex: All

Ages: 66+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Mild Cognitive Impairment

Exclusion criteria

• Diabetes
• Weight of under 100 or over 210 pounds
• Chronic use of pain medication

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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120 participants in 5 patient groups, including a placebo group

grape juice active intervention

Active Comparator group

Description:

Concord grape juice administered daily for 12 or 16 weeks

Treatment:

Dietary Supplement: Concord grape juice

juice placebo

Placebo Comparator group

Description:

berry placebo juice administered daily for 12 or 16 weeks

Treatment:

Dietary Supplement: placebo juice

blueberry juice active intervention

Active Comparator group

Description:

wild blueberry juice administered daily for 12 weeks

Treatment:

Dietary Supplement: blueberry juice

blueberry powder intervention

Active Comparator group

Description:

whole fruit blueberry powder administered daily for 16 weeks

Treatment:

Dietary Supplement: whole fruit blueberry powder

powder placebo

Placebo Comparator group

Description:

placebo powder administered daily for 16 weeks

Treatment:

Dietary Supplement: berry placebo powder