Oat Phenolics Bioavailability

University of Reading

Status: Completed

Conditions: Healthy

Treatments: Dietary Supplement: Oat bran; Dietary Supplement: refined grain

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT02574039

PROGRAIN1

Details and patient eligibility

About

A diet rich in whole grain is inversely associated with cardiovascular disease risk and this benefit could be partly attributed to the phenolic acid content of whole grains. The exact absorption, metabolism and excretion of whole grain phenolic acids, however, is not fully understood. In a small human intervention trial, the investigators will investigate to what extent phenolic acids from whole grain oats are absorbed, excreted in urine and how they are metabolised.

Enrollment: 7 patients

Sex: Male

Ages: 25 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Males
• 25 to 65 years old

Exclusion criteria

• Allergies to oats
• Parallel participation in another research project
• Having flu vaccination or antibiotics within 3 months of trial start
• Taking food supplements within 3 months of trial start
• Past or existing medical history of vascular disease, diabetes, hepatic, renal, gastrointestinal, haematological, neurological, thyroidal disease or cancer

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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7 participants in 2 patient groups, including a placebo group

Oat bran

Experimental group

Description:

66g oat bran made up in 350ml skimmed milk

Treatment:

Dietary Supplement: Oat bran

Control

Placebo Comparator group

Description:

Refined grain product and 350ml skimmed milk

Treatment:

Dietary Supplement: refined grain