Obesity and Brain: Genes and Environment

Amsterdam UMC, location VUmc

Status: Completed

Conditions: Obesity

Study type: Observational

Funder types: Other

Identifiers

NCT02025595

DC2013ObesiBrain001

91613082 (Other Grant/Funding Number)

NL 44735.029.13 (Other Identifier)

Details and patient eligibility

About

The aim of this study is to investigate the effects of genetic and environmental risk factors on central nervous system (CNS) reward and satiety circuits in the etiology of obesity. The investigators will also investigate to what extent the alterations in CNS reward and satiety circuits are a cause or a consequence of the development of obesity.

Enrollment: 92 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 18-75 years
• Male or female
• Stable bodyweight (<5% reported weight change during previous 3 months)
• Women: regular menstruation cycle (to exclude possible menstruation cycle effects)
• Normal fasting blood glucose

Exclusion criteria

• Left handedness
• Known diabetes or abnormal fasting blood glucose
• Serious heart, pulmonary, hepatic or renal disease, malignant or hematological disease
• Metabolic disorders (uncontrolled adrenal/thyroid disease)
• Women: irregular menstruation cycle
• Neurological or psychiatric illness
• Pregnancy or breast feeding
• Alcohol abuse
• Nicotine abuse
• Claustrophobia or metal implants
• Visual disability
• Participation in another study
• Inability to understand the protocol or to give informed consent
• Current/chronic use of following medication: antihyperglycemic agents, glucocorticoids, centrally acting drugs, cytostatics, immune suppressants, potentially addictive medications.

Trial design

92 participants in 2 patient groups

Monozygotic twin pairs

Description:

15 monozygotic twin pairs discordant for obesity

Genetic predisposition for obesity

Description:

15 obese and 15 non-obese individuals with a high genotype obesity risk score and 15 obese and 15 non-obese individuals with a low genotype obesity risk score. Genotype obesity risk score will be based on genome wide association single-nucleotide polymorphisms (SNP's) associated with obesity.