Obesity and Mortality of Critically Ill Patients With COVID-19 (COV-OB-ICU)

Central Hospital, Nancy, France

Status

Completed

Conditions

COVID

Obesity

Severe Acute Respiratory Syndrome

Comorbidities and Coexisting Conditions

Study type

Observational

Funder types

Other

Identifiers

NCT04425213

2020PI082

Details and patient eligibility

About

Disproportionate impact of COVID-19 in patients with obesity is now well established.

Obesity is associated with severe forms of COVID-19 and may be a risk factor of intensive care unit (ICU) admission. Obesity is associated with COVID-19 related hospital death in a large United Kingdom cohort study. However, there is a gap of knowledge on assessment of outcomes such as severity of Acute Respiratory Distress syndrome (ARDS), duration of hospitalisation and mortality in ICU. Moreover, an obesity survival paradox has been observed in patients with ARDS. This raises the question whether the obesity paradox has been broken by COVID-19.

The investigators aim to explore risk factors of in-ICU death for patient with COVID-19, including obesity and other chronic diseases and to describe the clinical course and outcomes, including the management of acute respiratory failure and other intensive care management.

Full description

The investigators aim to report ICU mortality for patients according to BMI category and to describe the detailed ICU clinical course of illness :

Risk factors for ICU mortality : age, sex, baseline comorbidities
Causes of death
Risk factors for use of non invasive mechanical ventilation
Non-fatal outcomes
Ventilator-free days
ICU length of stay.

Enrollment

250 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Adult patients with COVID-19 pneumonia admitted to ICUs between February 27th and April 18th 2020.
Infection confirmed by reverse transcriptase polymerase chain reaction assay or radiologically by chest computed tomography scan

Exclusion criteria