Obesity, Physical Inactivity or Dietary Fat ?

University Hospital, Strasbourg, France

Status

Completed

Conditions

Obesity

Treatments

Behavioral: Physical training

Study type

Interventional

Funder types

Other

Identifiers

NCT00434265

3493

Details and patient eligibility

About

Obesity is the consequence of a chronic disequilibrium of fat balance. Genetic factors determine predisposition to obesity, but the most often mentioned idea is that environmental factors, such as a high-fat diet and a sedentary lifestyle, join to favour weight gain and explain the increased prevalence of obesity in our westernized societies. Since lipogenesis is negligible in humans, obesity represents the consequence of altered fat partitioning between oxidation and storage, likely due to a preferential directing of dietary fat towards adipose tissue and away from muscle. Interventions that favour partitioning of dietary fat towards muscle for oxidation might thus protect against weight gain. Exercise may be one kind of such intervention but the scant data on dietary fat metabolism does not allow clear conclusions, in particular in obese subjects. One question concerns the impact of the type of fat eaten: the effects of physical inactivity may vary according to the length and saturation degree of the fatty acids. We hypothesize that 1) physical activity of moderate intensity, independently of its effect on energy balance, will favor a preferential trafficking towards adipose tissue, will modify the expression of genes implicated in fat oxidation and storage and partly correct the abnormalities observed in obese subjects, 2) effects of physical activity vary according to the saturation degree of fat. Twelve obese subjects, aged 18 to 55, will undergo tests before and after 2 months of training at current recommendations to ascertain dietary fat partitioning using stable isotopes and to determine changes in gene expression with muscle and adipose tissue microbiopsies.

Enrollment

12 patients

Sex

Male

Ages

18 to 55 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Men between 18 and 55
IMC >25 and <30 kg/m2 and waist circumference >102 cm
Familial antecedents of obesity
Physical inactivity (PAL<1.5, according to MOSPA-questionnaire and accelerometry)
Acceptation of physical training and body weight control during the study

Exclusion criteria

Any drug interfering with energetic or lipid metabolism
Any contradiction to moderate physical training
Diabetes or arterial hypertension treatment
Any other pathology (cardiovascular, psychiatric, renal or hepatic disease, viral hepatitis or VIH)
Consumption of more than 40 g alcohol per day
Recent voluntary or involuntary weight modification (3kg the next three months)
A recent trip outside France before and during stable isotope measures.