Obesity-related Genes in Taiwanese Undergoing Weight Loss

Sung Ling Yeh

Status: Completed

Conditions: Morbid Obesity

Treatments: Genetic: gender

Study type: Observational

Funder types: Other

Identifiers

NCT01684280

CRC-06-09-10

Details and patient eligibility

About

To investigate:

1. Associations between miRNA and insulin signaling-related gene expressions in abdominal adipose tissues in obese subjects.
2. Differences in miRNAs expressed by intrabdominal omental adipose tissues between genders.

Full description

Compared the differences in microRNA expressions of abdominal adipose tissue in morbid obese male and female subjects to elucidate the possible regulatory role of microRNA in insulin signaling-related gene expression levels and its association with biochemical markers. We hope to find a miRNA that can be used to predict the syndrome associated with obesity.

Enrollment: 20 patients

Sex: All

Ages: 19 to 63 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Morbid obesity,BMIs> 40 kg/m2
• Subjects who underwent bariatric surgery

Exclusion criteria

• Obese subjects with complicated metabolic disorders
• Thyroid disease

Trial design

20 participants in 1 patient group

gender

Description:

Paired samples of abdominal subcutaneous and intrabdominal omental adipose tissue were obtained from men and women who underwent bariatric surgery.

Treatment:

Genetic: gender