Obesity-related Inflammation in Patients Prior to and After Bariatric Surgery

University of Birmingham

Status: Completed

Conditions: Obesity; Morbid Obesity

Study type: Observational

Funder types: Other

Identifiers

NCT03283644

ERN_13-0355

Details and patient eligibility

About

This study investigates the chronic long-term health condition of obesity and its effect on neutrophil function and the inflammatory response

Full description

Inflammation is a central component of the immune response. In its acute form it aids the transition from disease to health via the activation of numerous immune cells, enabling them to reach the site of infection/injury and orchestrate themselves to combat pathogens, facilitating resolution and repair to restore the host to health. However, chronic inflammation is deleterious to the host and differs from the "classical" acute inflammatory process in that the inflammation is not necessarily so readily obvious and is not self-limiting; rather, the immune system is in a constant state of low-grade activation and when challenged by pathogenic or sterile injury the response is heightened, resulting in prolonged tissue damage and a failure of efficient resolution mechanisms.

Neutrophils are important mediators of acquired innate immune responses but may also contribute to the pathogenesis of chronic inflammatory diseases. Neutrophils are heavily involved in antimicrobial defence; their primary role is the localisation and elimination of pathogenic microorganisms. This, combined with their relatively short lifespan, has resulted in a traditional view of them as limited "kamikaze" cells. However, as detailed here, neutrophils have been shown to act with complexity and sophistication, orchestrating the immune/inflammatory response but also inadvertently contributing to tissue damage in different disease states. This study investigates the chronic long-term health condition of obesity and its effect on neutrophil function and the inflammatory response

Enrollment: 43 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria for Bariatric participants:

• BMI >40
• Undergoing Gastric Band surgery

Exclusion Bariatric Participants Criteria:

• Undergoing alternative weight loss surgery
• BMI<40
• Smoking
• Pregnancy

Exclusion criteria for the controls

• BMI over 27
• pregnancy
• smoking
• evidence of systemic disease
• use of medications/vitamin supplements.

Trial design

43 participants in 2 patient groups

Patients with a BMI over 40

Description:

Participants were aged between 27-65 years, BMI \>40 , Co-Morbidities associated with obesity including sleep apnoea, hypertension, depression, hypercholesterolaemia and type 2 diabetes, Undergoing Gastric Band surgery

Lean, healthy individuals

Description:

Participants were aged between 27-65 years, BMI\<28 , Systemically healthy, taking no prescribed medication