Objective Markers of Pain Perception in Humans

Centre Hospitalier Universitaire de Saint Etienne

Status: Completed

Conditions: Healthy

Treatments: Other: Painful tonic stimuli; Other: non-painful stimuli

Study type: Interventional

Funder types: Other

Identifiers

NCT02559999

2013-A01636-39 (Other Identifier)

1308172

Details and patient eligibility

About

Determine objective markers of pain perception remains a major scientific and medical issue. Various tools have been proposed to objectify pain, but their adaptability to different clinical contexts are limited. Our working hypothesis considers that the research for markers of immediate pain perception should be based on an electrophysiological approach, based on the combined analysis of EEG and autonomic responses.

Full description

This project aims to study the cortical and autonomic responses induced by tonic painful stimulation compared to those induced by comparable sensory and stressful stimulations, by combining high density EEG, cutaneous sympathetic, cardiovascular and pupillary recordings.

Enrollment: 21 patients

Sex: All

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Affiliate or beneficiary of social security
• Signature of consent

Exclusion criteria

• History of cardiovascular disease (vagal syncope, hypertension, etc ...), renal, metabolic (diabetes ...), psychiatric (depression, etc ...) or neurological (seizure, etc ...) syndromes;
• Reynaud's syndrome;
• Raynaud's disease;
• Acrocyanosis;
• Known rhythm disorders;
• Participation at the same time in another clinical trial;
• Taking a medical treatment;
• Suffering from acute (complaint of pain in the week before the test) or chronic pain,
• Allergic to conductive gel for electrodes.

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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21 participants in 1 patient group

EEG responses

Other group

Description:

The study compares electroencephalographical responses (EEG) to painful stimuli tonic to those evoked by non-painful stimuli and with or without virtual reality

Treatment:

Other: non-painful stimuli

Other: Painful tonic stimuli