Objective, Passive Assessment of LRRK2 Carriers (OPAL)

University of Rochester

Status: Completed

Conditions: Parkinson Disease

Treatments: Device: Emerald device

Study type: Observational

Funder types: Other

Identifiers

NCT05287620

STUDY00006771

Details and patient eligibility

About

The goal of this project is to identify objective, sensitive, and convenient measures for assessing early signs of Parkinson's disease in an at-risk population at home. We will do so by using a wireless sensor and analyzing the radio signals that bounce off patients' bodies, while patients go about their normal life without needing to wear sensors, answer questionnaires, or actively perform any tests.

Enrollment: 10 patients

Sex: All

Ages: 50+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• At least 50 years of age
• Able and willing to provide informed consent
• English fluency
• U.S. resident
• LRRK2 G2019S gene carrier, determined by participation in VALOR-PD
• Mild parkinsonian signs, determined by modified Movement Disorder Society-Unifeid Parkinson's Disease Rating Scale (MDS-UPDRS) score from the most recent VALOR-PD visit
• Have WiFi in their residence
• Access to a smartphone or tablet

Exclusion criteria

• Inability to complete study activities, as determined by the study team

• Any medical or psychiatric condition that, in the study team's judgement, would preclude participation

• Self-reported or VALOR-PD investigator determined Parkinson's disease

• Any movement disorder (e.g. essential tremor)

• Currently taking neuroleptics or other drugs known to cause parkinsonism

• Pregnancy

• Non-ambulatory status

• More than one ambulatory pet in the household*

• More than two individuals in the household (not including participant)*

  • these criteria can be waived at the discretion of the investigators