Observational Cohort of Pancreatic Echo-endoscopy (OBELIX)

Centre Hospitalier Saint Joseph Saint Luc de Lyon

Status: Completed

Conditions: Obesity; Hepatic Steatosis; Metabolic Syndrome

Treatments: Procedure: Endoscopic ultrasound

Study type: Observational

Funder types: Other

Identifiers

NCT04226014

OBELIX

Details and patient eligibility

About

Metabolic syndrome is defined by the presence of at least two of the following five criteria: abdominal perimeter> 94 cm in men, 80 cm in women, high triglycerides, low HDL cholesterol, HTA and hyperglycemia.

The metabolic syndrome can lead to ultrasound hepatic steatosis in 20 to 40% of cases depending on the population studied (overweight vs obesity). What is the impact of this syndrome on pancreatic echogenicity?

Full description

Little is known about the pathogenesis of the fatty pancreas. Fat can replace acinar cells and / or pancreatic endocrine cells (1). To date, there are no biomarkers allowing the detection of a fatty pancreas. It appears that older age, male, obesity, alcohol consumption, high triglycerides, high ALT, diabetes or insulin resistance, fatty liver and metabolic syndrome are risk factors for a fatty pancreas (2,3,4).To the investigator's knowledge, these different factors have not been evaluated on the impact of pancreatic echogenecity in endosonography. The objective of this study is to correlate the factors making up the metabolic syndrome with pancreatic echogenecity.

Enrollment: 97 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• any consecutive patient, having a high echo-endoscopy
• for an extra pancreatic cause, such as the search for a cholelithiasis, (the pancreas will be studied completely)
• for esophageal pathologies, (the pancreas will be studied completely)
• for gastric pathologies, (the pancreas will be studied completely)
• for cystic lesions of the pancreas (pancreas studied upstream and downstream)
• for submucosal tumors (esophageal / gastric / duodenal)
• for abdominal pain of undetermined origin

Exclusion criteria

• Patients with pancreatic and / or tissue damage with dilated wirsung canal and / or acute or chronic pancreatitis.
• Patients having contraindication to general anesthesia

Trial design

97 participants in 1 patient group

Patients with echo-endoscopic ultrasound of the pancreas

Description:

Patients requiring endoscopic ultrasound of the pancreas were included in the cohort.

Treatment:

Procedure: Endoscopic ultrasound