Observational Database on Deep Brain Stimulation in Tourette Syndrome (POSTSTIC)

Assistance Publique - Hôpitaux de Paris

Status: Enrolling

Conditions: Tourette Syndrome

Treatments: Other: Neurological and neuropsychological Follow-up after deep brain stimulation

Study type: Observational

Funder types: Other

Identifiers

NCT04449068

APHP190808

Details and patient eligibility

About

Within an ongoing deep brain stimulation (DBS) program for Tourette syndrome (TS) at the Department of Neurology, Pitié-Salpêtrière Hospital, Paris/France, the investigator team plans to evaluate patients pre-operatively and then at one year intervals post-operatively until the 5-year mark has been achieved. The investigator team will investigate tic severity, psychiatric co-morbidities, quality of life, and neuropsychological measures.

Full description

Since the completion of the STIC trial in 2017, the french team continues to offer DBS of the globus pallidus internus (GPi) to selected, treatment-refractory patients with TS. On average, three to four patients undergo surgery every year. Even though a first follow-up of the STIC cohort up to four years post-op indicates ongoing improvement of tic severity, many questions remains regarding the efficacy of GPi DBS in TS. These questions include frequent comorbidities of TS, quality of life, evolution of medication and stimulation parameters, as well as neuropsychological functioning. Therefore, the investigator proposes to evaluate all patients undergoing GPi DBS for TS to be evaluated comprehensively pre-operatively and once yearly after surgery until reaching the 5-year mark. The investigator team hopes these data may help to plan for future international multicenter trials, and provide indications on prognostic factors concerning response to GPi DBS in TS.

Enrollment: 20 estimated patients

Sex: All

Ages: 15+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Tourette syndrome severe and drug-resistant eligible for bilateral deep brain stimulation
• Person who voluntarily and knowledgeably agreed to participate in the study

Exclusion criteria

• Non affiliation to a French social security system (recipient or assign) excluding AME

Trial design

20 participants in 1 patient group

Evaluation of patients with Tourette's Gilles Syndrome

Description:

Neurological and neuropsychological evaluations of patients with Tourette's Gilles syndrome treated with high frequency bilateral stimulation of the anterior part of the internal pallid globus

Treatment:

Other: Neurological and neuropsychological Follow-up after deep brain stimulation