Observational, Prospective, Cohort Study of Mpox Infection in Brazil (NETPOX)

Hospital Israelita Albert Einstein

Status: Enrolling

Conditions: MPOX; Monkeypox

Treatments: Diagnostic Test: Viral genomic; Diagnostic Test: Untargeted Metabolomics

Study type: Observational

Funder types: Other

Identifiers

NCT05784038

NETPOX

Details and patient eligibility

About

The study is a prospective cohort that evaluates the clinical and immune-metabolic variables that may be linked to the risk and severity of the infection or even hospitalization or death in patients infected with the Mpox virus in Brazil. The expectation is to include at least 80 patients over six months, with a follow-up of 90 days from inclusion, through contact via decentralized visits.

Enrollment: 80 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Men and women aged ≥ 18 years with confirmed MPOX infection.

(laboratory-confirmed monkeypox infection is defined as determined by PCR, culture, or antigen test obtained from a sample collected from blood, oropharynx, anal or skin lesion within 4 days of randomization)

Exclusion criteria

• Inability to provide informed consent;
• Patient who, judging by the study team, does not have a condition for decentralized follow-up

Trial design

80 participants in 1 patient group

Human cases of monkeypox confirmed by PCR

Description:

Laboratory-confirmed mpox infection is defined as determined by polymerase chain reaction assay (PCR), culture, or antigen test obtained from a sample collected from blood, oropharynx, anal or skin lesion within 5 days of inclusion.

Treatment:

Diagnostic Test: Untargeted Metabolomics

Diagnostic Test: Viral genomic