Observational Study of Biomarker During Liver Surgery

University of Florida

Status: Terminated

Conditions: Liver Cancer; Hepatobiliary Tract Adenomas and Carcinomas

Treatments: Procedure: Hepatocellular carcinoma

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT02102971

IRB201400182 -N

R01DK079879 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The investigators would like to study whether Sirtuin 1 (SIRT1) plays a cytoprotective role in liver ischemia/reperfusion, and ultimately to develop therapeutic strategies to improve hepatic function of patients with liver diseases.

Full description

If asked to participate in this research study, it is because a liver resection/liver transplantation surgery has been scheduled. During the procedure a small section will be collected for additional testing of Sirtuin 1. In addition, information concerning the liver disease, laboratory and pathology results after surgery will be collected by the investigators.

Enrollment: 41 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• liver resection > 2 segments,
• plate count > 100 x 109/L, and
• prothrombin activity >60%.

Exclusion criteria

• liver cirrhosis,
• portal hypertension,
• steatohepatitis or severe steatosis,
• patients receiving additional ablation therapies,
• laparoscopic resection, and
• simultaneous extrahepatic procedures such as colorectal resection or pancreatoduodenectomy

Trial design

41 participants in 1 patient group

Hepatocellular carcinoma

Description:

Participants undergoing a liver resection/liver transplantation surgery. During the liver surgery a small piece of tissue will be removed to undergo additional laboratory testing.

Treatment:

Procedure: Hepatocellular carcinoma