Observational Study of Choline, Its Metabolites, and Phospholipids in Preterm Infants (NEO-CHOLIN)

University Hospital Tuebingen

Status: Completed

Conditions: Prematurity

Treatments: Other: collection of remnant of clinically indicated blood sample

Study type: Observational

Funder types: Other

Identifiers

NCT02027584

NEO-CHOLIN

Details and patient eligibility

About

To study concentrations of choline, its metabolites, and phospholipids in cord blood and remnants of clinically indicated blood samples

Full description

To collect cord plasma in preterm and term infants. To collect remnants of clinically indicated blood samples in parturients and hospitalized preterm infants during neonatal intensive care.

To determine concentrations of choline, its metabolites, and phospholipids by mass spectrometry.

To compare cord plasma concentrations with postnatal plasma concentrations.

Enrollment: 414 patients

Sex: All

Ages: Under 6 months old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• meeting criteria of the 4 cohorts

Exclusion criteria

• none pre-defined

Trial design

414 participants in 4 patient groups

parturient

Description:

mother who had given birth within 48 hours of clinically indicated blood sampling

Treatment:

Other: collection of remnant of clinically indicated blood sample

healthy, non-pregnant, female volunteers

Description:

healthy, non-pregnant, female volunteers

Treatment:

Other: collection of remnant of clinically indicated blood sample

preterm infant

Description:

gestational age at birth \< 37 weeks

Treatment:

Other: collection of remnant of clinically indicated blood sample

term infant

Description:

gestational age at birth \>36 weeks

Treatment:

Other: collection of remnant of clinically indicated blood sample