Observational Study of Iron Metabolism in Anemia in ICU and Post-Operative Patients (FAIRe)

Assistance Publique - Hôpitaux de Paris

Status: Completed

Conditions: Anemia; Cardiac Surgery; Intensive Care

Study type: Observational

Funder types: Other

Identifiers

NCT00338234

FAIRe

Details and patient eligibility

About

Anemia in intensive care and post-operative patients is due to both blood loss (leading to iron loss) and inflammation.

Full description

Anemia in intensive care and post-operative patients is due to both blood loss (leading to iron loss) and inflammation. The latter is known to interfere with iron metabolism, inducing iron storage instead of using it for hemoglobin synthesis. The discover of a new regulatory hormone of iron metabolism, hepcidin, may help us to better understand the link between inflammation and iron functional deficit. The aim of our study is to observe the variation of usual iron metabolism biological markers and of hepcidin, in order to define the better marker of iron loss in these clinical situations.

Enrollment: 153 patients

Sex: All

Ages: 20 to 88 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Anemia (haemoglobin < 10 g/dL)
• Hospitalization in ICU for an expected duration of 7 days or more
• Or, day one post cardiac surgery

Exclusion criteria

• Chronic anemia (Hb < 9 g/dL for more than one month before hospitalization)
• Iron metabolism disease

Trial design

153 participants in 2 patient groups

Cardiac surgery

Description:

Successive cardiac surgery patients

Surgical ICU

Description:

Successive patients admitted to the surgical ICU for more than 7 days, and experiencing anemia