Observational Study of Thrombogenic Properties in 220 Patients With Proximal Femur Fracture (thro-fract15)

Vestre Viken Hospital Trust

Status: Terminated

Conditions: Thromboembolism

Study type: Observational

Funder types: Other

Identifiers

NCT02475187

REK 2015/139

Details and patient eligibility

About

Measurement of thrombogenic properties by TEG and MEA and observation of thrombotic events over 2 years in 220 patients with hip fracture.

Full description

Patients with proximal femur fracture have high incidences of thrombotic events. By the two "bed-side" methods TEG (Thrombelastography) and MEA (Multiple Electrode Aggregometry), the thrombogenic properties of 220 patients with proximal femur fracture will be measured at time of hospital admission and 4 times over a period of 6 months postoperatively, and the patients will be followed in a total length of 2 years to register thrombotic events.

Enrollment: 33 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients older than 18 years who are admitted to our hospital for orthopedic surgery of proximal femur fracture.
• The study participants must be capable to sign/accept informed concent

Exclusion criteria

• Patients with severe dementia or that of other causes not ar capable to give informed concent.
• Patients with known or suspected cancer, blood diseases or bleeding disorders
• Surgery last 6 months
• Severe renal- (eGFR (creatinine) <30)
• Severe hepatic failure (2x UNL for bilirubin, 3x UNL for ALAT or INR > 1,3 without anticoagulation treatment)
• Patients that, by drug spesification or -SPC, not are eligible for postoperative thrombosis prophylaxis