Observational Study of Travellers Pathologies (EOP)

Pasteur Institute

Status: Enrolling

Conditions: Travel-Related Illness

Treatments: Other: Blood sample collection; Other: Fecal sample collection

Study type: Interventional

Funder types: Industry

Identifiers

NCT06701890

2023-A02574-41 (Other Identifier)

2022-069

Details and patient eligibility

About

Traveling to emerging countries is associated with a significant risk of encountering health issues specific to the destination, such as gastrointestinal and respiratory infections, malaria episodes, and road traffic accidents.These conditions are associated with behavioral, geographical, or environmental risk factors. A better understanding of these factors will enable the development of targeted recommendations to minimize travel related health issues.

The main objective of this study is to determine the incidence of pathologies occurring during travel outside the metropolitan territory.

Full description

Traveling to emerging countries is associated with a significant risk of encountering health issues specific to the destination, such as gastrointestinal and respiratory infections, malaria episodes, and road traffic accidents.These conditions are associated with behavioral, geographical, or environmental risk factors. A better understanding of these factors will enable the development of targeted recommendations to minimize travel related health issues.

The main objective of this study is to determine the incidence of pathologies occurring during travel outside the metropolitan territory.

Furthermore, two key aspects from a Public Health perspective are associated with travel and the globalization of exchanges: the acquisition of emerging pathogens or pathogens with antimicrobial resistance of concern.

To study these two aspects, the EOP study includes two sub-studies called EOP-Arbo and EOP-AMR.

• EOP-Arbo : The objective of this sub-study is to determine the risk of contracting an arboviral disease during travel, as well as the factors that may favor infection. For this, blood samples will be collected.
• EOP-AMR : The objective of this sub-study is to determine the risk of contracting an antibiotic-resistant bacteria during the trip. For this, faecal samples will be collected.

Enrollment: 11,000 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

1. Inclusion Criteria :

   1. For all participants in the EOP study :

      • Major subject (age ≥ 18)
      • Owns a smartphone compatible with electronic data collection
      • Preparing to travel outside mainland France
      • Affiliated with or covered by Social Security or private insurance
      • Willing to participate in the EOP study

   2. For the EOP-Arbo Sub-study :

      • Subject who has consented to participate in the EOP_Arbo study.

   3. For the EOP-AMR Sub-study :

      • Subject who has consented to participate in the EOP_AMR study.

2. Exclusion Criteria:

   1. For all participants in the EOP study :

      • Travel duration ≤ 3 days
      • Travel duration > 12 months
      • Person traveling as part of an expatriation without planned movement outside the settlement in the destination country
      • Person under legal protection or unable to express consent for participation

   2. For the EOP-Arbo Sub-study :

      • Individuals deemed clinically and/or biologically unfit by the investigator to undergo the blood samples required for the study.

   3. For the EOP-AMR Sub-study :

      • No specific exclusion criteria.

Trial design

Primary purpose: Prevention

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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11,000 participants in 1 patient group

Adults planning to travel outside metropolitan France.

Experimental group

Description:

Human biological samples : * Blood sample * fecal sample

Treatment:

Other: Fecal sample collection

Other: Blood sample collection