Observational Study on the Patients With Rectal Cancer

Chinese Academy of Medical Sciences & Peking Union Medical College

Status

Completed

Conditions

Adjuvant Chemotherapy

Neoadjuvant Chemoradiotherapy

Surgery

Adjuvant Chemoradiotherapy

Rectal Cancer

Study type

Observational

Funder types

Other

Identifiers

NCT02312284

CAMS 14-122/912

Details and patient eligibility

About

The aim of this observational study is to retrospectively collect current survival data for 3995 primary rectal cancer patients who were extracted from 5097 rectal cancer patients admitted in Cancer Hospital, Chinese Academy of Medical Sciences from January 2000 to December 2010. Moreover, based on a Cox model, we want to develope a nomogram that predicts local recurrence, distant metastases, and survival for patients with rectal cancer treated with pre- or postoperative chemoradiotherapy (CRT).

Enrollment

3,995 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Aged older than 18 years
American Joint Committee on Cancer (six edition) stage I through IV disease
Received either transabdominal resection, transanal excision, preoperative radiotherapy or chemoradiotherapy
Had the histologic subtypes adenocarcinoma (not otherwise specified, mucinous or mucin-producing, mixed cell or with mixed subtypes, tubular, and papillary)

Exclusion criteria

Had the histologic subtypes squamous cell carcinoma, carcinoid, neuroendocrine tumor, small cell carcinoma, leiomyosarcoma, sarcoma, gastrointestinal stromal sarcoma, melanoma, carcinosarcoma, rhabdoid tumors, or malignant peripheral nerve sheet tumors
Only receive palliative surgery such as colostomy, sigmoidostomy
Received palliative radiotherapy or chemoradiotherapy for metastatic disease
With unresectable distant metastasis in liver, lung, bone, central nervous system , or peritoneal transplantation
Had no detailed medical records