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Observational Study on the Patients With Rectal Cancer

Chinese Academy of Medical Sciences & Peking Union Medical College logo

Chinese Academy of Medical Sciences & Peking Union Medical College

Status

Completed

Conditions

Adjuvant Chemotherapy
Neoadjuvant Chemoradiotherapy
Surgery
Adjuvant Chemoradiotherapy
Rectal Cancer

Study type

Observational

Funder types

Other

Identifiers

NCT02312284
CAMS 14-122/912

Details and patient eligibility

About

The aim of this observational study is to retrospectively collect current survival data for 3995 primary rectal cancer patients who were extracted from 5097 rectal cancer patients admitted in Cancer Hospital, Chinese Academy of Medical Sciences from January 2000 to December 2010. Moreover, based on a Cox model, we want to develope a nomogram that predicts local recurrence, distant metastases, and survival for patients with rectal cancer treated with pre- or postoperative chemoradiotherapy (CRT).

Enrollment

3,995 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Aged older than 18 years
  • American Joint Committee on Cancer (six edition) stage I through IV disease
  • Received either transabdominal resection, transanal excision, preoperative radiotherapy or chemoradiotherapy
  • Had the histologic subtypes adenocarcinoma (not otherwise specified, mucinous or mucin-producing, mixed cell or with mixed subtypes, tubular, and papillary)

Exclusion criteria

  • Had the histologic subtypes squamous cell carcinoma, carcinoid, neuroendocrine tumor, small cell carcinoma, leiomyosarcoma, sarcoma, gastrointestinal stromal sarcoma, melanoma, carcinosarcoma, rhabdoid tumors, or malignant peripheral nerve sheet tumors
  • Only receive palliative surgery such as colostomy, sigmoidostomy
  • Received palliative radiotherapy or chemoradiotherapy for metastatic disease
  • With unresectable distant metastasis in liver, lung, bone, central nervous system , or peritoneal transplantation
  • Had no detailed medical records

Trial design

3,995 participants in 3 patient groups

Radiotherapy/Chemoradiotherapy
Description:
Pre- or postoperative or palliative radiotherapy/chemoradiotherapy based on 5-fluorouracil or Capecitabine +/-Oxaliplatin
Surgery
Description:
Transabdominal resection or transanal excision
Chemotherapy
Description:
Pre- or postoperative chemotherapy including 5-fluorouracil/leucovorin with oxaliplatin, Capecitabine, etc

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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