Observational Study on the Treatment of Trigeminal Neuralgia by Radiosurgery (NATURE)

Princess Grace Hospital Center (CHPG)

Status: Enrolling

Conditions: Trigeminal Neuralgia

Study type: Observational

Funder types: Other

Identifiers

NCT05677243

21-19

Details and patient eligibility

About

This study aims to evaluate the outcome of patient treated by radiosurgery on LINAC with high dose rate for classical trigeminal neuralgia

Full description

This retrospective and prospective case-series hospital-based study will be conducted in all patients with trigeminal neuralgia treated by radiosurgery on LINAC at the Centre Hospitalier Princesse Grace from april 2018 to january 2028. Patients will be treated with frameless technic and receive 90 Gy delivered with high dose rate on the intra cisternal portion of the trigeminal nerve.

Enrollment: 150 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Classical trigeminal neuralgia according the International Classification of Headache Disorders
• Trigeminal neuralgia resistant to the maximum tolerated medical therapy, with pain intensity according to the Barrow Neurological Institute (BNI) score IV or V.
• Patients aged > 18

Exclusion criteria

• Patients suffering from secondary Trigeminal neuralgia (tumour in the cerebellopontine angle, arteriovenous malformation or multiple sclerosis)
• Previous history of radiosurgery procedure