Observational Study on the Variation of Ascorbic Acid in Patients Undergoing Solid Organ Transplantation (REDOX-TX)

Policlinico Hospital

Status: Active, not recruiting

Conditions: Ascorbic Acid Deficiency; Transplantation

Study type: Observational

Funder types: Other

Identifiers

NCT06395259

3334

Details and patient eligibility

About

The objective of this observational clinical study is to evaluate the variations in ascorbic acid during the transplantation phases and how these variations influence the oxidative status and patient outcome.

The main questions it aims to answer are:

• how many patients arrive at the transplant in a state of hypovitaminosis C?
• how does hypovitaminosis C affect the patient's oxidative status?
• how does hypovitaminosis C affect the length of stay in intensive care and post-transplant complications?

Full description

Researches will compared:

Differences between Hypovitaminosis Group and Normal Range Group Changes in oxidative stress markers before and after solid organ transplantation Incidence of allograft dysfunction between groups Incidence of acute kidney injury and other complications between groups

Enrollment: 40 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients undergoing solid organ transplantation (liver or kidney or lung)

Exclusion criteria

• Minor patients
• Multi-organ transplantation

Trial design

40 participants in 2 patient groups

Hypovitaminosis Group

Description:

Patients who at the end of surgery have sub-optimal plasma ascorbic acid levels, i.e. with concentrations lower than 28 µmol/L

Normal Range Group

Description:

Patients who at the end of surgery have plasma ascorbic acid levels equal to or greater than 28 µmol/L