Observing the Relationship of Fibroblast Growth Factor and Fibroblast in Thyroid Eye Disease (TED)

National Taiwan University

Status: Unknown

Conditions: Graves Ophthalmopathy

Study type: Observational

Funder types: Other

Identifiers

NCT03324022

201412026RINB

Details and patient eligibility

About

Graves' orbitopathy (GO) affects about 50% of patients with Graves' disease (GD), and some cannot be cured by current treatments. Orbital fibroblasts involves in the pathogenesis of GO by producing glycosaminoglycans and inflammatory cytokines. Since fibroblast growth factors (FGFs) binding to FGF receptors (FGFRs) can induce proliferation and differentiation of fibroblasts, investigators would like to measure the expression of FGFs and FGFRs in GO patients to see if inhibition of FGF-FGFR pathway has potential in treatment.

Enrollment: 80 estimated patients

Sex: All

Ages: 20 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• diagnosed as thyroid eye disease
• suggested to accept orbital decompression

Exclusion criteria

• age below 20 or above 80
• pregnancy