Interstitial Lung Disease and Obstructive Sleep Apnea

Dan Liu

Status: Enrolling

Conditions: ILD OSA

Treatments: Diagnostic Test: The relationship between imaging and ROSE and NGS

Study type: Observational

Funder types: Other

Identifiers

NCT05838183

Dliu

Details and patient eligibility

About

Clinically, all patients with interstitial lung disease(ILD) were observed, and relevant clinical data were collected. Bronchoscopic specimens were collected according to the condition of the enrolled patients, and the rapid on site evaluation(ROSE) was evaluated, combined with the metagenomic next generation sequencing(mNGS) results of these patients. To observe the etiology and biological characteristics of exacerbation in patients with interstitial lung disease.

All patients undergo polysomnography (PSG) and drug-induced sleep endoscopy(DISE). The biological specimens was obtained for molecular biology or other tests.We detected Claudin1, Claudin2, Claudin3, Claudin4, and IL22 as biomarkers to differentiate the diagnostic efficiency of OSA in ILD, ILD+OSA, OSA, and Ctrl groups, respectively

Enrollment: 70 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• over 18 years old and under 80 years old.
• Clinical diagnosis of interstitial lung disease or obstructive respiratory sleep apnea syndrome.
• Patient is conscious and capable of signing informed consent.
• The patient may wear a polysomnograph.

Exclusion criteria

• malignant tumors.
• severe heart failure.
• uremia.
• autoimmune diseases.
• pulmonary embolism, and end-stage chronic obstructive pulmonary disease.
• Patients with mental illnesscannot sign informed consent on their own.

Trial design

70 participants in 2 patient groups

ILD with OSA group

Description:

ILD patient diagnosed with OSA by PSG. Bronchoscopy was performed to obtain alveolar lavage fluid in ILD patients and lung tissue was obtained for ROSE and mNGS in appropriate patients

Treatment:

Diagnostic Test: The relationship between imaging and ROSE and NGS

ILD without OSA

Description:

ILD patients excluded OSA through PSG. Bronchoscopy was performed to obtain alveolar lavage fluid in ILD patients and lung tissue was obtained for ROSE and mNGS in appropriate patients

Treatment:

Diagnostic Test: The relationship between imaging and ROSE and NGS