Obstructive Sleep Apnea and Non-alcoholic Fatty Liver Disease (NASHSAS)

University Hospital, Angers

Status: Unknown

Conditions: Sleep Apnea, Obstructive; Non-alcoholic Fatty Liver Disease

Treatments: Diagnostic Test: OSA screening

Study type: Interventional

Funder types: Other

Identifiers

NCT03373643

UHAngers

Details and patient eligibility

About

Obstructive sleep apnea (OSA) and nonalcoholic fatty liver disease (NAFLD) are frequently encountered in patients with metabolic syndrome (MS). Several data suggest that OSA per se could be a risk factor of liver injury. Most previous studies evaluating the association between OSA severity and the severity of NAFLD used indirect markers of NAFLD including liver imaging or liver injury blood markers or have been performed in morbidly obese patients undergoing intraoperative needle liver biopsy during bariatric surgery.

The current study propose to investigate with a full night polysomnography consecutive patients undergoing percutaneous liver biopsy for suspected NAFLD.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Suspected NAFLD requiring per-cutaneous liver biopsy

Exclusion criteria

• Other than NAFLD liver disease
• Previously diagnosed or treated OSA
• Excessive alcohol consumption (>220 gr/week for men, >140 gr/week for women)
• Pregnancy
• Surgical treatment for obesity past history

Trial design

Primary purpose: Screening

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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100 participants in 1 patient group

Patient suspected for NAFLD

Experimental group

Treatment:

Diagnostic Test: OSA screening