Obstructive Sleep Apnea in the Absence of Metabolic Syndrome

Associação Fundo de Incentivo à Pesquisa

Status and phase

Completed

Phase 4

Conditions

Obstructive Sleep Apnea

Treatments

Procedure: continuous positive airway pressure (CPAP)

Study type

Interventional

Funder types

Other

Identifiers

NCT01635010

ASSIMVOP012

Details and patient eligibility

About

Obstructive Sleep Apnea (OSA) is commonly associated with factors that increase cardiovascular risk, including Metabolic Syndrome (MS). There is a lack of well-controlled clinical studies investigating the independent effects of OSA in the development of cardiovascular disease, especially evaluating jointly mechanisms involved in these disorders such as inflammatory response, oxidative stress and vascular changes. The investigators hypothesized that in the absence of MetS, the mechanisms involved on cardiovascular consequences in OSA patients would be less important.

The purpose of this study is to analyze the effects of OSA in the absence of MS, on inflammatory, oxidative stress and vascular markers; to verify the influence of excessive daytime sleepiness (EDS) on the same parameters; and additionally verify the effects of nasal continuous positive airway pressure (nCPAP)in theses parameters.

Enrollment

34 patients

Sex

Male

Ages

25 to 60 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

male subjects
apnea-hypopnea index > 15/h (OSA group)
apnea-hypopnea index < 5/h (control group)

Exclusion criteria

body mass index (BMI) > 30 kg/m2
age > 60 years
chronic obstructive pulmonary disease
cardiac diseases
diabetes mellitus
metabolic syndrome according to modified National Cholesterol Education Program Adult Treatment Panel III criteria
previous OSA treatment