Obstructive Sleep Apnea Syndrome and Attention Executive Function Disturbances

Shamir Medical Center (Assaf-Harofeh)

Status: Unknown

Conditions: Obstructive Sleep Apnea

Study type: Observational

Funder types: Other

Identifiers

NCT00757796

143/06

Details and patient eligibility

About

Studies demonstrate that sleep disturbances are associated with cognitive dysfunction and attention deficit. However the correlation between the severity of obstructive sleep apnea and the degree of cognitive dysfunction was not demonstrated. Our hypothesis is that patients suffering from a more severe sleep apnea will demonstrate a greater degree of cognitive dysfunction.

Full description

Studies demonstrate that sleep disturbances are associated with cognitive dysfunction and attention deficit. However the correlation between the severity of sleep disturbances and the degree of cognitive dysfunction was not demonstrated.We intend to study 80 patients with various degrees of obstructive sleep apnea. All patients will undergo executive cognitive tests as well as tests to assess for levels of depression, anxiety and attention.

Enrollment: 80 estimated patients

Sex: All

Ages: 20 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Apnea hypopnea index>5
2. Age 20 - 70 years

Exclusion criteria

1. Pregnant women
2. Known chronic cardiovascular or pulmonary disease
3. Patients s/p CVA or brain damage
4. Known depression or other psychiatric disorder
5. Patients with severe cognitive dysfunction (MMSE<25)
6. Patients receiving stimulants, antipsychotic or anti-depression medications