Obstructive Sleep Apnoea and Adipose Tissue Dysfunction

NHS Foundation Trust

Status: Completed

Conditions: Hypoxia; Obesity; Obstructive Sleep Apnoea

Treatments: Device: Continuous positive airway pressure devices

Study type: Observational

Funder types: Other

Identifiers

NCT02518633

OSAadipose

Details and patient eligibility

About

Dysfunctional adipose tissue predisposes to cardiovascular disease. Similarly, the risk of cardiovascular disease appears to be increased in subjects with obstructive sleep apnoea. Reduced adipose tissue oxygen availability has been described in obesity and may also be a mechanism in obstructive sleep apnoea. Hypoxia induces inflammation and fibrosis in adipose tissue which are factors contributing to cardiovascular risk. The investigators hypothesize that adipose tissue's oxygen uptake is reduced in subjects with obstructive sleep apnoea by comparing in vivo AT oxygenation and blood flow in tissue of control subjects.

Full description

Assessment includes a adipose tissue biopsy and measurement of oxygenation and blood flow by a Clarke type electrodes and non-invasive Doppler techniques.

Enrollment: 15 patients

Sex: Male

Ages: 18 to 90 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• men with or without obstructive sleep apnoea

Exclusion criteria

• weight loss interventions
• steroid use
• active smoking

Trial design

15 participants in 2 patient groups

men with obstructive sleep apnoea

Description:

Continuous positive airway pressure devices

Treatment:

Device: Continuous positive airway pressure devices

control subjects

Description:

subjects with no obstructive sleep apnoea