Obstructive Sleep Apnoea in Adolescents With Thoracic Aortic Aneurysm (OSA in TAA)

University of Zurich (UZH)

Status: Completed

Conditions: Thoracic Aortic Aneurysm Without Rupture; Obstructive Sleep Apnea

Study type: Observational

Funder types: Other

Identifiers

NCT03400319

KEK-ZH-Nr. 2014-0035 CTRL

Details and patient eligibility

About

The objective of this prospective cohort study is to determine the prevalence of obstructive sleep apnoea (OSA) in patients with and without thoracic aortic aneurysm.

Full description

The objective of this prospective cohort study is to determine the prevalence of obstructive sleep apnoea (OSA) in patients with and without thoracic aortic aneurysm.

Enrollment: 174 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age > 18 years.
• Diagnosis of thoracic aortic aneurysm defined by the following parameters:

Women: at the level of the sinus of valsalva ≥39mm, or ascending aorta ≥42mm. (for controls: <39mm and <42mm respectively); Men: at the level of the sinus of valsalva ≥44mm, or ascending aorta ≥46mm. (for controls: <44mm and <46mm respectively)

Exclusion criteria

• Patients on continuous positive airway pressure (CPAP) therapy for OSA at baseline.
• Patients with known central sleep apnoea.
• Patients on morphine or other opioid medication, heroin addiction, alcohol addiction.
• Patients with moderate or severe aortic regurgitation.
• Patients with moderate or severe aortic stenosis.
• Pregnant patients.

Trial design

174 participants in 2 patient groups

Thoracic Aortic Aneurysm

Description:

Patients with Thoracic Aortic Aneurysm: Women: at the level of the sinus of valsalva ≥39mm, or ascending aorta ≥42mm. Men: at the level of the sinus of valsalva ≥44mm, or ascending aorta ≥46mm.

No Thoracic Aortic Aneurysm

Description:

Patients without Thoracic Aortic Aneurysm: Women: at the level of the sinus of valsalva \<39mm, or ascending aorta \<42mm. Men: at the level of the sinus of valsalva \<44mm, or ascending aorta \<46mm.