Occupational Respiratory Allergies and Gene-environment Interactions (ARPEIGE)

Central Hospital, Nancy, France

Status

Unknown

Conditions

Work Related Asthma

Treatments

Other: Blood sample

Study type

Observational

Funder types

Other

Identifiers

NCT02879838

ANSES-2013/ARPEIGE-PENVEN/MS

Details and patient eligibility

About

The purpose is to compare clinical, functional, professional and socio-economical characteristics of patients with occupational asthma and work aggravated asthma.

Secondary purposes are:

to evaluate diagnostic value of new non-invasive techniques such as exhaled nitric oxide and cytology of induced expectoration;
to estimate medical-social becoming of diagnosed work-related asthma after one year;
to establish a biobank of blood samples of individuals with work related asthma for measurement of cytokines and search for genetic polymorphisms associated with asthma.

Full description

Participants with work related asthma or suspected work related asthma will obtain a precise diagnosis concerning severity and control of respiratory disorder and also the possible effect of professional environment on the disorder. Their medical care and medico-legal care, in case of recognition of occupational disease, could be ameliorated.

In general, this study will allow the harmonization of diagnostic care and medical, medico-professional and medico-legal management of cases of work related asthma in specialized hospitals.

Enrollment

400 estimated patients

Sex

All

Ages

16 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patient consulting for suspected work-related asthma in one of hospitals participating to the study

Exclusion criteria

Patient refusing to participate
Pregnant or breastfeeding women
Individual in life-threatening emergency
Hospitalized patient
Patient in a health or social institution
Person deprived of liberty
Person with total occupational disability
Retired person
Person diagnosed as non-asthmatic
Asthmatic person already enrolled in a clinical trial of bio-therapy to treat asthma