OCEAN Registry: Obesity and Clock for Elegant Aging Registry

Chang Gung Medical Foundation

Status: Enrolling

Conditions: Aging; Circadian Dysregulation; Obesity; Cardiovascular Disease

Study type: Observational

Funder types: Other

Identifiers

NCT02674230

100-0250A3

Details and patient eligibility

About

This study aims to study the relationships between obesity, circadian rhythm, and aging. The investigators set up a prospective cohort registry for morbid obesity, obesity, and normal subjects with annual follow-up. The cohort aims to investigate the pathophysiological, molecular, genetic, and cellular aspects of the relationships between obesity, circadian deregulation, and impacts on aging. Clinical data, questionnaires, biological material, and molecular signatures will be collected and investigated.

Full description

The objective of this observational study is the follow-up of 2000 adult obesity (BMI ≥ 35 and 24-35 kg/m2) and non-obese subjects with annual follow-up for 10 years. Clinical data, biochemistry, and biological samples (serum, DNA, RNA, white blood cells) will be collected and stored. Adipose tissues will be collected if participants received liposuction, plastic surgery, bariatric surgery, dermatological procedure, intra-abdominal operation, and cardiovascular surgery. Questionnaires will be obtained with special nurse including sleep quality, chronotypes, and circadian activities. During follow up period, major adverse cardiovascular events will be monitored.

The investigators anticipate that the results generated from the study will provide valuable data to a better understanding of the relationships between obesity, circadian rhythm, and aging.

Enrollment: 2,000 estimated patients

Sex: All

Ages: 20+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age ≥ 20 years old
• Body mass index ≥ 24 kg/m2
• For normal subjects, Body mass index < 24 kg/m2

Exclusion criteria

• No inform consent
• Use of steroid medications
• Severe systemic diseases or organ failure with estimated life expectancy of 6 months or less

Trial design

2,000 participants in 3 patient groups

Extreme obesity

Description:

BMI ≥35kg/m2

Obesity

Description:

BMI 24-34.9kg/m2

Normal subjects

Description:

BMI \<24kg/m2. No systemic disease, including hypertension, diabetes, liver cirrhosis, chronic kidney disease, and psychiatric disease.