OCTA Analysis In Children After Lensectomy

Wenzhou Medical University

Status: Unknown

Conditions: Deprivation Amblyopia

Treatments: Device: Optical Coherence Tomography Angiography

Study type: Interventional

Funder types: Other

Identifiers

NCT04217772

OCTA-LZL

Details and patient eligibility

About

The aim of this study is to quantify and compare the foveal avascular zone (FAZ), the parafoveal and foveal vessel density of superficial (SCP) and deep capillary plexus (DCP) and retinal thickness in deprivation amblyopic eyes, fellow non-amblyopic eyes, and age-matched normal eyes, using optical coherence tomography angiography (OCTA). The FAZ, parafoveal and foveal SCP and DCP, and retinal thickness were measured in normal controls and at least 3 months postoperatively in children with unilateral cataract and compared between groups after adjusting for axial length and spherical equivalents.

Enrollment: 100 estimated patients

Sex: All

Ages: 3 to 18 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• children after cataract surgery and healthy volunteers

Exclusion criteria

• presence of corneal opacity preventing detailed imaging
• nystagmus
• retinal disease,
• persistent fetal vasculature
• intraocular inflammation,
• glaucoma
• vitreoretinal surgery
• premature birth
• neurologic disease
• systemic disease that could alter microvasculature (including diabetes, hypertension, cardiovascular disease and renal disease)

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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100 participants in 2 patient groups

Eyes post-lensectomy

Experimental group

Description:

Eyes of children after cataract surgery

Treatment:

Device: Optical Coherence Tomography Angiography

Healthy Eyes

No Intervention group

Description:

Eyes of healthy volunteers