Ocular Changes With Alpha-2 Receptor Agonist.

Benha University

Status: Enrolling

Conditions: Aberration, Corneal Wavefront; Glaucoma, Suspect

Treatments: Drug: High dosage selective alpha-2 receptor agonists topical eyedrop; Drug: Low dosage selective alpha-2 receptor agonists topical eyedrop

Study type: Interventional

Funder types: Other

Identifiers

NCT05670015

RC-2-2023

Details and patient eligibility

About

selective alpha-2 receptor agonists cause changes in intraocular pressure and pupillary size thus may affect patient quality of life.

Full description

In this research, we will analyze the effect of selective alpha-2 receptor agonists on the human eye and investigate ocular changes over 6 months after its topical use.

Enrollment: 150 estimated patients

Sex: All

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Glaucoma suspect cases.
• post-refractive surgery cases.

Exclusion criteria

• Cases with prostatic hyperplasia or diabetics that may alter the measurements of pupillary diameter.
• Cases with previous history of any retinal intervention or other drugs that may alter intraocular pressure measurements.

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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150 participants in 2 patient groups

Glaucoma suspect group

Active Comparator group

Description:

Cases diagnosed as glaucoma suspect

Treatment:

Drug: High dosage selective alpha-2 receptor agonists topical eyedrop

Drug: Low dosage selective alpha-2 receptor agonists topical eyedrop

Post-refractive surgery group

Active Comparator group

Description:

Cases had undergone refractive surgery

Treatment:

Drug: High dosage selective alpha-2 receptor agonists topical eyedrop

Drug: Low dosage selective alpha-2 receptor agonists topical eyedrop