Ocular Microvascular Changes in Patients With Sepsis

Lithuanian University of Health Sciences

Status: Completed

Conditions: Retinal Microcirculation Disorder; Conjunctiva; Disorder; Sepsis

Treatments: Device: Incident dark field videomicroscope from Braedius; Device: Fundus camera from Optomed

Study type: Observational

Funder types: Other

Identifiers

NCT04214743

2018/BE-2-18

Details and patient eligibility

About

This study evaluates differences in the ocular microcirculation between septic patients and healthy subjects and the course of ocular microvasculature in survivors and non-survivors over a 24 hours period of time in septic patients

Full description

Conjunctival imaging, using IDF video microscope, and retinal imaging, using portable digital fundus camera, as well as systemic hemodynamic measurements, were performed in septic patients at three time points: at baseline, 6 hours and 24 hours. Baseline conjunctival and retinal microcirculatory parameters were compared with healthy controls.

Enrollment: 76 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• adult patients with sepsis or septic shock within the first 24 hours after ICU admission

Exclusion criteria

• psychiatric disorders, brain diseases, chronic alcoholism, autoimmune rheumatic diseases
• ophthalmological diseases, such as glaucoma, age-related macular degeneration, diabetic retinopathy and cataract