Office Hysteroscopy and Endometrial Snip Improve Intrauterine Insemination Outcome

Cairo University (CU)

Status and phase: Completed; Phase 3

Conditions: Infertility

Treatments: Procedure: Office hysteroscopy; Procedure: Office hysteroscopy and endometrial snip

Study type: Interventional

Funder types: Other

Identifiers

NCT01544426

42012

Details and patient eligibility

About

Endometrial injury had been studied before prior to intracytoplasmic sperm injection (ICSI) cycles , in cases of repeated implantation failure. It is found that it will improve the implantation rate.

Full description

The investigators can combine office hysteroscopy to diagnose hidden endometrial pathology, with hysteroscopically guided endometrial snip from the fundus of the uterus, trying to improve the pregnancy rate.

Enrollment: 332 patients

Sex: Female

Ages: 18 to 38 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18- 38 years old
• at least one patent tube
• unexplained infertility, anovulation, mild to moderate male factor infertility
• previous failed IUI

Exclusion criteria

• indicated for ICSI

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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332 participants in 2 patient groups

Office hysteroscopy and endometrial snip

Experimental group

Description:

Office hysteroscopy and endometrial snip

Treatment:

Procedure: Office hysteroscopy and endometrial snip

Office hyteroscopy

Active Comparator group

Description:

Office hysteroscopy

Treatment:

Procedure: Office hysteroscopy