OLA to Lowest DP in Cardiac Surgery

Fundación para la Investigación del Hospital Clínico de Valencia

Status: Unknown

Conditions: Lung Collapse

Treatments: Procedure: RM-5; Procedure: DP-PEEP

Study type: Interventional

Funder types: Other

Identifiers

NCT03133754

DP-PEEP

Details and patient eligibility

About

This study aims to compared the effects in driving pressure of an open-lung strategy with a positive end-expiratory pressure (PEEP) titrated to best driving pressure (DP) after a RM versus the recommended protective PEEP of 5 cmH2O without a recruitment manuever in non-obese patients undergoing cardiac surgery.

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Non-obese patients scheduled for cardiac surgery (CABG and valve replacement)

Exclusion criteria

• i) age <18yr or >80yr, ii) pregnancy or breast-feeding status, and iii) patients with previous known respiratory disease, iv) Body mass index >35 kg/m2, v) emergency surgery and vi) hemodynamic instability at entry (need of vasopressors or ionotropes at entry or a ventricular assist device.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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60 participants in 2 patient groups

DP-PEEP

Experimental group

Description:

recruitment maneuver + individualized PEEP

Treatment:

Procedure: DP-PEEP

RM-5

Active Comparator group

Description:

recruitment maneuver + fixed standard PEEP

Treatment:

Procedure: RM-5