Olanzapine in the Treatment of Hair Pulling (Trichotillomania)

Hamilton Health Sciences (HHS)

Status and phase

Completed

Phase 4

Conditions

Trichotillomania

Treatments

Drug: Olanzapine

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT00182507

00-167

Details and patient eligibility

About

Trichotillomania (TTM) or hair-pulling has been considered as part of the obsessive compulsive disorder (OCD) spectrum, although treatment with OCD medications has largely been unsuccessful. Tics/Tourrettes' Syndrome (TS) is a disorder, which appears to be related to TTM, but is treated with a different class of medications than used in OCD, namely antipsychotics such as olanzapine. This is a study of the safety and efficacy of olanzapine in the treatment of hair pulling.

Sex

All

Ages

18 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

primary DSM-IV trichotillomania; CGI-Severity ≥ 4

Exclusion criteria

Any other Axis I primary diagnosis; CGI-S < 4; current comorbid: OCD, MDD, alcohol or substance abuse; lifetime hx of: schizophrenia, bipolar affective disorder or dementia; current pregnancy/lactation; current suicidality or homicidality; major medical problems or clinically unstable medical disease; hx of: seizures, stroke or head trauma; prior use of neuroleptics