Older Adult Training Study With Creatine and CLA (OTR)

Hamilton Health Sciences (HHS)

Status: Completed

Conditions: Sarcopenia

Treatments: Drug: Creatine Monohydrate, Conjugated Linoleic Acid; Behavioral: Training

Study type: Interventional

Funder types: Other

Identifiers

NCT00473902

Older Adult Training Study

Details and patient eligibility

About

We examined whether creatine monohydrate (CrM) and conjugated linoleic acid (CLA) could enhance strength gains and improve body composition (i.e., increase fat-free mass (FFM); decrease body fat) following resistance exercise training in older adults (> 65 y). Our study hypothesized that administering CrM and CLA would yield greater strength and body composition benefits than the placebo group over the six months of resistance exercise

Full description

Men (N=19) and women (N=20) completed six months of resistance exercise training with Creatine Monohydrate (5g/d) + Conjugated Linoleic Acid (6g/d) or placebo with randomized, double-blind, allocation.Outcomes included; strength and muscular endurance, functional tasks, body composition (DEXA scan), blood tests (lipids, liver function, CK, glucose, systemic inflammation markers (IL-6, C-reactive protein)), urinary markers of compliance (creatine/creatinine), oxidative stress (8-OH-2dG, 8-isoP) and bone resorption (Ν-telopeptides).

Enrollment: 39 patients

Sex: All

Ages: 65 to 85 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy,
• Ambulatory,
• Recreationally active,
• Community dwelling

Exclusion criteria

• Evidence of coronary heart disease;
• Congestive heart disease;
• Uncontrolled hypertension;
• Chronic obstructive pulmonary disease;
• Diabetes mellitus;
• Renal failure;
• Major orthopedic disability; and
• Smoking

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind