-Oleoyl Glycerol is a GPR119 Agonist and Signals GLP-1 Release in Humans.

Glostrup University Hospital, Copenhagen

Status: Completed

Conditions: Type 2 Diabetes

Treatments: Dietary Supplement: GPR 119 agonist, 2-oleyl glycerol; Dietary Supplement: Vehicle; Dietary Supplement: Oleic acid

Study type: Interventional

Funder types: Other

Identifiers

NCT01043445

GPR119

Details and patient eligibility

About

The purpose of this study is to evaluate the impact of different ligands of GPR 119 (a G protein-coupled receptor in the intestine) on the secretion of the incretin hormones, GLP-1 and GIP.

Full description

We have found a new ligand for the GPR 119 receptor. This study evaluate the impact of this ligand on the incretion hormone responses, beta cell function and gall bladder function in healthy young men.

Enrollment: 8 patients

Sex: Male

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy caucasians v- Normal OGTT (75 g of glucose) according to WHO's criteria
• Normal hemoglobin
• Informed consent

Exclusion criteria

• Liver disease (ALAT> 2x normal level)
• Nephropathy (s-creatinin >130 microM or albuminuria)
• Relatives with type 2 diabetes

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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8 participants in 3 patient groups, including a placebo group

GPR119 agonist, 2-oleoyl glycerol

Experimental group

Description:

2-oleoyl glycerol; 2g. and vehicle

Treatment:

Dietary Supplement: GPR 119 agonist, 2-oleyl glycerol

Dietary Supplement: Vehicle

Oleic acid

Active Comparator group

Description:

oleic acid; 3.2g and vehicle

Treatment:

Dietary Supplement: Vehicle

Dietary Supplement: Oleic acid

Vehicle

Placebo Comparator group

Description:

5 ml. of glycerol and 5 ml 96% ethanol

Treatment:

Dietary Supplement: Vehicle