Olfaction Disorders in Patients Included in The Trauma Brain Injury (TBI) Database at Trondheim University Hospital

St. Olavs Hospital

Status: Completed

Conditions: Olfaction Disorders; Brain Injuries

Treatments: Drug: corticosteroids; Behavioral: olfactory stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT02565121

2013/427

Details and patient eligibility

About

The aim of the study is to see whether patients with chronic smell impairment after brain injury benefit from a treatment that consists of corticosteroids, and then olfactory training in 3 months.

Enrollment: 20 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Registered in the TBI Database
• 18-65 years of age per 01.10. 2012
• Olfaction score by Sniffin Sticks Threshold-Discrimination-Identification (TDI) < 30 confirming dysosmia

Exclusion criteria

• Unable to express senses.
• Unable to follow treatment and protocol
• pregnancy
• diabetes
• tendency to infections
• hypertonia
• dyspepsia
• interfering medication (hormonal treatment, NSAIDS, antidiabetics, barbiturates, fenitoin, carbamazepin, rifampicin, cyclophosphamides)

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

20 participants in 1 patient group

Olfactory disorder after brain trauma

Experimental group

Description:

Recruited from 250 patients with moderate to severe traumatic brain injury in the Hodeskadeprosjektet (TBI) cohort. Treatment with (first) corticosteroids and (second) olfactory stimulation.

Treatment:

Behavioral: olfactory stimulation

Drug: corticosteroids