Olfactogustatory Perception, Eating Behaviour and Inflammation in Crohn's Disease (Smell&Crohn)

University Hospital Center (CHU) Dijon Bourgogne

Status: Completed

Conditions: Olfactogustatory Perception; Crohn's Disease

Treatments: Other: triangular test; Biological: blood sampling; Other: Questionnaires

Study type: Observational

Funder types: Other

Identifiers

NCT02859675

BRONDEL Ass INRA 2011

Details and patient eligibility

About

This study will improve our understanding of the mechanisms underlying anorexia in persons with Crohn's disease flare-ups. The practical spin-off from this research is potentially very important for the management of nutritional disorders associated with the disease by guiding diets towards foods that correspond to patients' preferences and/or to modified tastes. In addition, the results could lead to the identification of sensory markers that herald an inflammatory flare-up of the disease.

Enrollment: 62 patients

Sex: Female

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

For patients :

Inclusion Criteria:

• Age between 18 and 60 years,
• Diagnosis of Crohn's disease according to clinical, endoscopic, histological, radiological and biochemical criteria as defined by the European Consensus Conference,
• Men or women who have provided consent and willing to cooperate.

Exclusion Criteria:

• Chronic inflammatory intestinal disease (CIID) other than Crohn's disease: haemorrhagic rectocolitis, undetermined colitis, microscopic colitis.
• Intercurrent disease (diabetes and metabolic disease, liver cirrhosis, progressive cancer, acute or chronic infection, Human Immunodeficiency Virus HIV),
• Organ failure (respiratory, heart, or renal failure, neurological disorders),
• Intolerance to gluten,
• Treatments (other than those used for Crohn's disease) able to interfere with food intake,
• Aversion to foods consumed or smelled,
• Poor understanding of cognitive tasks required.
• Crohn's disease complicated by an abscess or infectious complication
• Acute Crohn's disease defined by a CDAI score > 150

For Controls:

Inclusion Criteria:

• Adult person
• Without follow-up for a chronic pathology
• Having given its consent

Exclusion Criteria:

• Protected adult
• Person not affiliated to a social security system
• Pregnant or breastfeeding woman
• Active smoker
• No one who does not speak French
• Taking treatment that interferes with taste or acts on the central nervous system

Trial design

62 participants in 3 patient groups

Crohn and anti-TNF treatment

Description:

Tests at 3 or 4 weeks after the beginning of anti-TNF treatment

Treatment:

Other: Questionnaires

Other: triangular test

Biological: blood sampling

Crohn and without anti-TNF treatment

Description:

tests performed according to patient availability

Treatment:

Other: Questionnaires

Other: triangular test

Biological: blood sampling

Control

Description:

tests performed according to patient availability

Treatment:

Other: Questionnaires

Other: triangular test

Biological: blood sampling