Olfactory Decision-making and Deprived Sleep (ODDS)

Northwestern University

Status: Completed

Conditions: Sleep Deprivation

Treatments: Behavioral: Sleep deprivation

Study type: Interventional

Funder types: Other

Identifiers

NCT05093413

STU00215342

Details and patient eligibility

About

This research study will use magnetic resonance imaging (MRI) and olfactory stimuli to better understand the connection between sleep deprivation, brain activity, and olfaction in humans.

Enrollment: 46 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• At least 18 years old
• Fluent English speakers

Exclusion criteria

• History of neurological conditions (e.g., epilepsy, dementia, multiple sclerosis, brain tumors, etc.)
• History of psychiatric conditions (e.g., general anxiety disorder, depression, schizophrenia, obsessive-compulsive disorder, post-traumatic stress disorder, attention deficit hyperactivity disorder, alcoholism, etc.)
• Significant medical illnesses (e.g., cancer, meningitis, chronic obstructive pulmonary disease, cardiovascular disease, etc.)
• Cerebrovascular risk factors (e.g., hypertension, diabetes, elevated cholesterol, etc.)
• Use of psychoactive medications (e.g., barbiturates, benzodiazepines, chloral hydrate, haloperidol, lithium, carbamazepine, phenytoin, citalopram, escitalopram, fluoxetine, diazepam, etc.)
• Smell or taste dysfunction
• History of severe allergies requiring hospitalization for treatment
• History of severe asthma requiring hospitalization for treatment
• Habitual smoking
• History of eating disorders (e.g., anorexia nervosa, bulimia nervosa, binge-eating disorder, etc.)
• Dieting or fasting
• History of sleep disorders (e.g., obstructive sleep apnea, narcolepsy, insomnia, etc.) Magnetic implants (e.g., shunts or stents, aneurysm clips, surgical clips, cochlear implants, metal bone/joint pins, plates and screws, eyelid spring or wires, etc.)
• Electronic implants (e.g., implanted cardiac defibrillator, cardiac pacemaker, deep brain/spinal cord or nerve stimulator, internal electrodes/wires, medication infusion devices, etc.)
• History of metal working without proper eye protection, or injury with metal shrapnel or metal slivers
• Left-handedness
• Claustrophobia

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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46 participants in 2 patient groups

Fully slept first; Sleep deprived second

Experimental group

Description:

Participants will be fully slept during the first experimental visit and sleep deprived during the second experimental visit

Treatment:

Behavioral: Sleep deprivation

Sleep deprived first; Fully slept second

Experimental group

Description:

Participants will be sleep deprived during the first experimental visit and fully slept during the second experimental visit

Treatment:

Behavioral: Sleep deprivation