Olfactory Stimulation for Very Low Birth Weight Infants

Fudan University

Status: Completed

Conditions: Very Low Birth Weight Infant

Treatments: Behavioral: Routine nursing care; Behavioral: Olfactory stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT05406804

NICU olfactory stimulation-01

Details and patient eligibility

About

This is a RCT study examining whether odor administration to mothers of very low birth weight infants promotes stabilization of vital signs compared with common nursing care. This study used breast milk olfactory stimuli familiar and liked by premature infants to understand the effects of olfactory stimuli on the physiological indicators of very low birth weight infants, the effect on the time of complete enteral nutrition, and the effects on growth and development of very low birth weight infants.

Full description

Fluctuations in vital signs of very low birth weight infants may lead to poor prognosis. Research Objectives:

To evaluate the effect of olfactory stimulation of breast milk on the stability of physiological indexes of very low birth weight infants Subjects: Very low birth weight infants whose gestational age are less than 32 weeks.

Enrollment: 60 patients

Sex: All

Ages: Under 24 hours old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Gestational age at birth <32 weeks;
• Birth weight < 1500 g;
• Admission to hospital within 24 hours after birth;
• Mother can provide breast milk

Exclusion criteria

• Severe congenital malformations;
• Complicated congenital heart disease;
• Congenital gastrointestinal disease;
• Intraventricular hemorrhage

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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60 participants in 2 patient groups

Breast milk olfactory stimulation care

Experimental group

Description:

Let premature babies smell their mother's breast milk

Treatment:

Behavioral: Olfactory stimulation

Routine care

Active Comparator group

Description:

Prevent premature babies from smelling their mother's breast milk

Treatment:

Behavioral: Routine nursing care