OLGA Stage is More Appropriate in Predicting Early Gastric Cancer

Shanghai Jiao Tong University School of Medicine

Status: Completed

Conditions: Early Gastric Cancer

Treatments: Other: gastric atrophy and intestinal metaplasia

Study type: Observational

Funder types: Other

Identifiers

NCT02562976

rjxhnk3062

Details and patient eligibility

About

The aim of the present study was to evaluate characteristics of background mucosa in early gastric cancer (EGC), and to seek for the optimal assessment for EGC screening.

Full description

Japanese endoscopic gastric atrophy (EGA) classification, operative link on Gastritis Assessment (OLGA), operative link on intestinal metaplasia assessment (OLGIM) and gastritis pattern are used in evaluating the severity of gastritis and intestinal metaplasia in different countries, which are risk factors of gastric cancer. The aim of the present study was to evaluate characteristics of background mucosa in early gastric cancer (EGC), and to seek for the optimal assessment for EGC screening.

A prospective study was conducted encompassing EGC patients (cases) and non-EGC patients (controls). All patients were performed endoscopic examination and systematically biopsied. Outcome measures were assessed and compared, including EGA classification as well as the OLGA/OLGIM assessment. Helicobacter pylori(H. pylori) status was detected in the meantime. A stepwise logistic regression model was performed to analyze correlations between EGA, OLGA, OLGIM and EGC.

Enrollment: 227 patients

Sex: All

Ages: 40 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• The age of patients is from 40-80 years
• Must undergo esophagogastroduodenoscopy

Exclusion criteria

• Clinical diagnosis of advanced gastric cancer
• Post-subtotal gastrectomy
• Acute upper gastrointestinal bleeding
• Severe systemic diseases
• Lack histology

Trial design

227 participants in 2 patient groups

early gastric cancer group

Description:

use Japanese endoscopic gastric atrophy classification, Operative Link on Gastritis Assessment (OLGA), Operative Link on Gastric Intestinal Metaplasia Assessment (OLGIM) to evaluate the severity of gastric atrophy and intestinal metaplasia in patients with early gastric cancer or high-grade neoplasia(HGN)

Treatment:

Other: gastric atrophy and intestinal metaplasia

non-early gastric cancer group

Description:

patients diagnosed as non- gastritis, gastritis or low-grade neoplasia (LGN) by pathology were defined as non-EGC group

Treatment:

Other: gastric atrophy and intestinal metaplasia