Oligodendrocyte Progenitor Cell Culture From Human Brain

Rajavithi Hospital

Status and phase: Completed; Phase 1

Conditions: Demyelinating Diseases

Treatments: Procedure: Oligodendrocyte progenitor cell culture/craniotomy

Study type: Interventional

Funder types: Other

Identifiers

NCT00283023

RH-CMR-003

RVH-CMR-003 grant

Details and patient eligibility

About

Recent developments in the understanding of stem- and progenitor cell differentiation raises hopes that brain damage in chronic neurological diseases may become repaired by systemic or focal transplantation of such cells. Clinical trials of stem- or progenitor cell transplantation in multiple sclerosis are currently premature. The researchers developed a protocol for human oligodendrocyte progenitor cell culture from human brain for the treatment of demyelinating disease.

Full description

Oligodendrocyte progenitor cell line were cultures and will be transplanted into the patient with Multiple sclerosis.

Enrollment: 5 patients

Sex: All

Ages: 20 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Male or female 20-65 years of age
• Informed consent
• Has elective craniotomy surgery

Exclusion criteria

• HIV, hepatitis, and other central nervous system (CNS) infections
• Dementia, Alzheimer disease, and neurodegenerative disease

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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5 participants in 1 patient group

A

Experimental group

Description:

Progenitor cells from the patinets with Craniotomy with V-P Shunt or ventriculostomy will be collected and cultured.

Treatment:

Procedure: Oligodendrocyte progenitor cell culture/craniotomy